Date(s) - 20 Feb 2014
10:00 AM - 11:30 AM
3043 ECpE Building Addition
Title: Biosensing and Diagnostics Enabled by Micro-Nanotechnologies
Speaker: Long Que, John Cordaro/Entergy Endowed Associate Professor, Louisiana Tech University
Abstract: Nanomaterials and nanostructures have become the enabling technology for enhancing the performance of the micro-nanodevices (bioMEMS) for biosensing and diagnostics. These devices and systems would have broad impact in health care, biomedical engineering, life science, and personalized medicine.
The objective of research at our lab is to develop a variety of new nanostructure-enabled bio-analytical tools with improved functionality and performance. Optical and electrical effects on biomolecules and cells in micro-nanoscale domains are utilized for enhancing the performance of these devices and systems. Detection is achieved with both fluorescence and label-free methods.
In this talk, two research topics will be presented. The first is about a fluorescence-enhancement platform. Specifically, the aluminum oxide nanostructure substrate for fluorescence enhancement has been discovered by our lab, which offers many potential exciting applications such as immunosensing, DNA sequencing, and single molecule imaging. The second is about a nanostructured Fabry-Perot interferometer (NanoFPI). By integrating Au-coated nanopores inside the cavity of a FPI, the sensitivity of the NanoFPI can be improved significantly compared to the conventional FPI. Using the NanoFPI, the cancer biomarker can be detected at a concentration as low as femtomolar level with high specificity and selectivity. This technical platform can be developed for point-of-care (POC) diagnostics, given its operational simplicity, inexpensiveness and portability.
Speaker Bio: Long Que is currently a John Cordaro/Entergy Endowed Associate Professor at Louisiana Tech. He previously worked at GE-Global Research Center. He received his PhD in Electrical Engineering from University of Wisconsin-Madison. He was a visiting scholar at the Center for Wireless Integrated Microsystems at University of Michigan at Ann Arbor and at the Center for Nanoscale Materials at Argonne National Laboratories. His current research interests are bionanotechnology, bioMEMS, nanomaterials and nanodevices enabled by self nanoassembly technique for biomedical applications. Dr. Que has authored two book chapters. He has published over 60 papers in major conferences and journals and has over 25 granted and pending US patents. Dr. Que received a national research award from Chinese Academy of Sciences in 1997. He won invention awards from GE. He is a recipient of NSF-CAREER Award in 2009. He received outstanding research and invention awards from Louisiana Tech and from Board of Regents of Louisiana in 2009 and 2011.