Faculty Seminar – Liang Dong

When

February 27, 2015    
1:10 pm - 2:00 pm

Where

3043 ECpE Building Addition
Coover Hall, Ames, Iowa, 50011

Event Type

Title: Lab on a chip enables high throughput detection of electrophysiological and biomechanical signals of microscopic nematodes.

Speaker: Liang Dong, ECpE Associate Professor

Abstract: The use of small animal models has become increasingly important for biological studies and drug screening. Existing molecular mechanisms for detecting altered genotype associated with drug resistance are not able to easily translate to observable changes in phenotype. To aid drug selection for treatments, and development and use of new drugs that counter resistant parasites, the MEMS and Biochip Laboratory at Iowa State has been developing a chip-scale system for detecting different important parameters of motility, electrophysiology, and biomechanics for microscopic nematodes, aiming at realizing deep and accurate phenotyping at high throughput. The presentation will include our recent research results on the topic of developing (1) an ultrahigh-sensitivity force sensor for testing the muscular force or biomechanical implications of nematodes responding to various drug environments; (2) a single-larval-worm capture device for exposing nematodes to drug-coded liquid droplets, (3) a microelectrodes-based locomotion tracking system for high-throughput behavioral phenotyping, and (4) a high-resolution electrophysiological recording device.

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